Cholesterol on Trial: When High LDL Leads to Heart Disease—and When It Doesn’t

He wasn’t exactly a poster child for heart health. He loved steak, hated vegetables, and didn’t care much for doctors. His LDL-cholesterol hovered around 200 mg/dL (5.17 mmol/L) for most of his adult life. Yet, at age 88, his arteries were clean—and his mind sharper than ever. Meanwhile, his neighbor—an avid cyclist with “perfect” cholesterol—underwent … Read more

The Difference Between LDL-Cholesterol (LDL-C) and LDL Particle Number(LDL-P)

The role of low-density lipoprotein cholesterol (LDL-C) in the evolution of heart disease is fairly well established. In addition, the benefits of pharmacological treatment with agents that lower LDL-C in high-risk patients are well documented. Lipoproteins are biochemical structures that enable the transport of lipids such as cholesterol in the circulation. LDL-C represents the amount … Read more

Apolipoprotein B (ApoB) and Risk of Heart Disease

Apolipoprotein B (ApoB) is a protein that plays an important role in the development of heart disease. Elevated blood levels of ApoB indicate an increased risk. Actually, ApoB may be a stronger predictor of risk than commonly used lipid markers such as LDL-cholesterol (1). ApoB is an important component of lipoproteins that participate in the … Read more

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