Polycystic Ovary Syndrome (PCOS) – From Symptoms to Diagnosis and Treatment

Polycystic ovary syndrome (PCOS) is a common disorder among women. It is characterized by menstrual irregularities, infertility, signs of androgen excess, and polycystic ovaries. It is often associated with obesity, insulin resistance, and lipid abnormalities. PCOS is the most common cause of infertility in women (1). PCOS was first described in 1934 by Irving F. Stein … Read more

Uric Acid, Hyperuricemia, and Gout

More than eight million people in the U.S., almost 4% of the population, are estimated to suffer from gout. The disease often causes severe pain and physical disability. Gout is associated with increased blood levels of uric acid, called hyperuricemia. Uric acid is a biochemical substance the body has to deal with through our lifetime. It is an end … Read more

Evolocumab (Repatha) for Heart Disease – The FOURIER Trial – Success or Failure?

The eagerly awaited results of the FOURIER trial were recently presented at the Annual Meeting of the American College of Cardiology (ACC) in Washington DC and simultaneously published in the New England Journal of Medicine (1). The goal of FOURIER was to evaluate the efficacy and safety of evolocumab (Repatha), a PCSK9 inhibitor, among subjects with elevated risk … Read more

The FOURIER Trial – Are We Entering a New Era in Cardiovascular Medicine?

The results of the recently completed FOURIER trial suggest that we have taken a huge step forward in the pharmacological therapy atherosclerotic cardiovascular disease (ASCVD). On February 2, 2017 the biotechnological company Amgen announced that the FOURIER trial evaluating whether the drug evolocumab (Repatha) reduces the risk of cardiovascular events in patients with clinically evident ASCVD … Read more

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